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C-C Chemokine Receptor Type 8 (CCR8) Antibody
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Catalogue No: abx025739
Price:
US$326.25
(Size: 80 µl)
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CCR8 encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. CCR8 is located at the chemokine receptor gene cluster region.
Research Articles on C-C Chemokine Receptor Type 8 (CCR8)
| Target | C-C Chemokine Receptor Type 8 (CCR8) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 290-317 amino acids from the C-terminal region of human CCR8. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P51685 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RC64, Q3KNQ8, Q3KNR3, Q9BYX5 |
| UniProt Entry Name | CCR8_HUMAN |
| KEGG | hsa:1237 |
| String | 9606.ENSP00000326432 |
| Molecular Weight | Calculated MW: 40.8 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |