Neprilysin / NEP (MME) Antibody

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Catalogue No: abx010513
Price: US$420.50
(Size: 100 µl)

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Datasheet SDS
CD10 (MME): membrane metallo-endopeptidase. This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.

Target Neprilysin / NEP (MME)
Clonality Monoclonal
Reactivity Human
Tested Applications ELISA, IHC
Host Mouse
Recommended dilutions ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Purified recombinant fragment of human CD-10 expressed in E. coli.
Isotype IgG2b
Form Liquid
Purification Unpurified ascites.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P08473 (UniProt, ExPASy)
UniProt Secondary AC A8K6U6, D3DNJ9, Q3MIX4
UniProt Entry Name NEP_HUMAN
Gene Symbol MME
GeneID 4311
OMIM 120520
HGNC 7154
KEGG hsa:4311
Ensembl ENSG00000196549
String 9606.ENSP00000418525
Molecular Weight 85 kDa
Buffer Ascitic fluid containing 0.03% sodium azide.
Concentration Not determined.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Neprilysin / NEP (MME)


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