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Programmed Cell Death Protein 1 Ligand 1 / PD-L1 (CD274) Antibody

Catalogue No: abx001385
Price: £120.00
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Programmed Cell Death Protein 1 Ligand 1 / PD-L1 (CD274) Antibody Programmed Cell Death Protein 1 Ligand 1 / PD-L1 (CD274) Antibody

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Programmed Cell Death 1 Ligand 1 Antibody is a Rabbit Polyclonal antibody against PD-L1 (CD274). Programmed cell death ligand 1 (CD274, or B7-H1, PD-L1) is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.

Target Programmed Cell Death Protein 1 Ligand 1 / PD-L1 (CD274
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 19-238 of human PD-L1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q9NZQ7 (UniProt, ExPASy)
UniProt Secondary AC B2RBA2, B4DU27, Q14CJ2, Q2V8D5, Q66RK1, Q6WEX4, Q9NUZ5
UniProt Entry Name PD1L1_HUMAN
Gene Symbol CD274
GeneID 29126
String 9606.ENSP00000370989
Molecular Weight Calculated MW: 20 kDa, 33 kDa
Observed MW: 43 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration 3 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Programmed Cell Death Protein 1 Ligand 1 / PD-L1 (CD274) Antibody

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