Tumor Necrosis Factor Receptor Superfamily Member 8 / CD30 (TNFRSF8) Antibody

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF- kappa B. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Target	Tumor Necrosis Factor Receptor Superfamily Member 8 / CD30 (TNFRSF8)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human CD30 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P28908 (UniProt, ExPASy)
UniProt Secondary AC	B1AN79, B9EGD9, D3YTD8, Q6P4D9
UniProt Entry Name	TNR8_HUMAN
Gene Symbol	TNFRSF8
GeneID	943
OMIM	153243
HGNC	11923
KEGG	hsa:943
Ensembl	ENSG00000120949
String	9606.ENSP00000263932
Molecular Weight	64 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Tumor Necrosis Factor Receptor Superfamily Member 8 / CD30 (TNFRSF8)

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