Platelet And Endothelial Cell Adhesion Molecule 1 (PECAM1) Antibody

CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM1), is a type I integral membrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors.It is constitutively expressed on the surface of endothelial cells, and concentrated at the junction between them. The antibody reacts with the murine form of the Platelet-Endothelial Cell Adhesion Molecule. The reactivity of the antibody is restricted to the isoform of the molecule that is selectively expressed by endothelial cells.The antigen is predominantly present at the lateral borders of endothelial cells as described for human PECAM-1.It is also weakly expressed on many peripheral lymphoid cells and platelets.CD31 has been used to measure angiogenesis in association with tumor recurrence. Other studies have also indicated that CD31 and CD34 can be used as markers for myeloid progenitor cells and recognize different subsets of myeloid leukemia infiltrates (granular sarcomas).

Target	Platelet And Endothelial Cell Adhesion Molecule 1 (PECAM1)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IHC, IF/ICC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human CD31 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P16284 (UniProt, ExPASy)
UniProt Entry Name	PECA1_HUMAN
Gene Symbol	PECAM1
GeneID	5175
OMIM	173445
HGNC	8823
KEGG	hsa:5175
Ensembl	ENSG00000261371
String	9606.ENSP00000457421
Molecular Weight	100 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Platelet And Endothelial Cell Adhesion Molecule 1 (PECAM1)

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