Myeloid Cell Surface Antigen CD33 (CD33) Antibody
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Catalogue No: abx027453
Price:
US$326.25
(Size: 80 µl)
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Datasheet SDS
Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2, 6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase (s) via their SH2 domain (s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
Research Articles on Myeloid Cell Surface Antigen CD33 (CD33)
| Target | Myeloid Cell Surface Antigen CD33 (CD33) |
| Research Area | Cellular Differentiation and Adhesion, Hematology |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 88-117 amino acids from the Central region of human CD33. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P20138 (UniProt, ExPASy) |
| UniProt Secondary AC | B4E3P8, C9JEN7, F8WAL2, Q8TD24 |
| UniProt Entry Name | CD33_HUMAN |
| Gene Symbol | CD33 |
| KEGG | hsa:945 |
| String | 9606.ENSP00000262262 |
| Molecular Weight | Calculated MW: 39.8 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |