Cyclic ADP Ribose Hydrolase (CD38) Antibody
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Catalogue No: abx010525
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US$427.75
(Size: 100 µl)
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Datasheet SDS
CD38 is a type II integral membrane glycoprotein which is present on early B and T cell lineages and activated B and T cells but is absent from most mature resting peripheral lymphocytes. CD38 is also found on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, monocytes and Ig-secreting plasma cells. CD38 acts as a NAD glycohydrolase in T lym- phocytes. On hematopoietic cells CD38 induces activation, proliferation, and differentiation of mature T and B cells and mediates apoptosis of myeloid and lymphoid progenitor cells. In addition to acting as a signaling receptor, CD38 is also an enzyme capable of producing several calcium-mobilizing metabo- lites, including cyclic adenosine diphosphate ribose (cADPR). CD38 also plays a role in maintaining survival of an invariant NK T (iNKT) cell subset that preferentially contributes to the maintenance of immunological tolerance.
Research Articles on Cyclic ADP Ribose Hydrolase (CD38)
| Target | Cyclic ADP Ribose Hydrolase (CD38) |
| Research Area | Signal Transduction, Cellular Differentiation and Adhesion, Enzymes and Kinases, Metabolic Pathways, Tumor Immunity, Infection Immunity, Endocrinology, Bone Metabolism, Cancer |
| Clonality | Monoclonal |
| Reactivity | Human |
| Tested Applications | ELISA, IHC |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human CD38 expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P28907 (UniProt, ExPASy) |
| UniProt Secondary AC | O00121, O00122, Q96HY4 |
| UniProt Entry Name | CD38_HUMAN |
| Gene Symbol | CD38 |
| GeneID | 952 |
| OMIM | 107270 |
| HGNC | 1667 |
| KEGG | hsa:952 |
| Ensembl | ENSG00000004468 |
| String | 9606.ENSP00000226279 |
| Molecular Weight | 34 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |