TNF Receptor Superfamily Member 5 / TNFRSF5 (CD40) Antibody

CD40 Antibody is a Rabbit Polyclonal antibody against CD40. This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Target	TNF Receptor Superfamily Member 5 / TNFRSF5 (CD40)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence within amino acids 198-277 of human CD40.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P25942 (UniProt, ExPASy)
UniProt Secondary AC	E1P5S9, Q53GN5, Q5JY15, Q5U007, Q7M4Q8, Q86YK5, Q9BYU0
UniProt Entry Name	TNR5_HUMAN
Gene Symbol	CD40
GeneID	958
NCBI Accession	NP_001241.1
KEGG	hsa:958
String	9606.ENSP00000361359
Molecular Weight	Calculated MW: 31 kDa Observed MW: 45 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	2.36 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on TNF Receptor Superfamily Member 5 / TNFRSF5 (CD40)

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