Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC) Antibody

CD45, also known as TPRC (protein tyrosine phosphatase, receptor type, C). The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.

Target	Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IHC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of CD45 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P08575 (UniProt, ExPASy)
UniProt Secondary AC	A0A0A0MT22, A8K7W6, Q16614, Q9H0Y6, X6R433
UniProt Entry Name	PTPRC_HUMAN
Gene Symbol	PTPRC
GeneID	5788
OMIM	126200
HGNC	9666
KEGG	hsa:5788
Ensembl	ENSG00000081237
String	9606.ENSP00000411355
Molecular Weight	155 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC)

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