Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC) Antibody

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Catalogue No: abx028663
Price: US$326.25
(Size: 80 µl)

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Datasheet SDS
CD45 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. The CD45 gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling.

Target Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC)
Clonality Polyclonal
Reactivity Human
Tested Applications ELISA, WB, IHC, FCM
Host Rabbit
Recommended dilutions WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 1245-1275 amino acids from the C-terminal region of human CD45.
Isotype IgG
Form Liquid
Purification Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P08575 (UniProt, ExPASy)
UniProt Secondary AC A0A0A0MT22, A8K7W6, Q16614, Q9H0Y6, X6R433
UniProt Entry Name PTPRC_HUMAN
KEGG hsa:5788
String 9606.ENSP00000411355
Molecular Weight Calculated MW: 147 kDa
Buffer PBS containing 0.09% sodium azide.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC)


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