Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC) Antibody
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Catalogue No: abx028663
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US$326.25
(Size: 80 µl)
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Datasheet SDS
CD45 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. The CD45 gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling.
Research Articles on Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC)
| Target | Receptor-Type Tyrosine-Protein Phosphatase C / CD45 (PTPRC) |
| Research Area | Signal Transduction, Tumor Immunity, Infection Immunity, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 1245-1275 amino acids from the C-terminal region of human CD45. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P08575 (UniProt, ExPASy) |
| UniProt Secondary AC | A0A0A0MT22, A8K7W6, Q16614, Q9H0Y6, X6R433 |
| UniProt Entry Name | PTPRC_HUMAN |
| KEGG | hsa:5788 |
| String | 9606.ENSP00000411355 |
| Molecular Weight | Calculated MW: 147 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |