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CD59 Glycoprotein (CD59) Antibody

Catalogue No: abx001417
Price: £120.00
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CD59 Glycoprotein (CD59) Antibody CD59 Glycoprotein (CD59) Antibody CD59 Glycoprotein (CD59) Antibody

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CD59 Antibody is a Rabbit Polyclonal antibody against CD59. This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008].

Target CD59 Glycoprotein (CD59)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human CD59.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P13987 (UniProt, ExPASy)
UniProt Secondary AC E9PR17
Gene Symbol CD59
GeneID 966
Molecular Weight Calculated MW: 14 kDa
Observed MW: 17 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on CD59 Glycoprotein (CD59) Antibody

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