CD59 Glycoprotein (CD59) Antibody

CD59 Glycoprotein Antibody is a Rabbit Polyclonal antibody against CD59 Glycoprotein. CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex (MAC), whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This inhibitor appears to be species-specific. This protein also plays a role in signal transduction for T-cell activation complexed to a protein tyrosine kinase. CD59 deficiency results in hemolytic anemia and thrombosis, which can lead to cerebral infarction.

Target	CD59 Glycoprotein (CD59)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/1000 - 1/5000, IHC: 1/20 - 1/200, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant human CD59 glycoprotein (26-102 AA).
Isotype	IgG
Form	Liquid
Purity	> 95%
Purification	Purified by Protein G.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P13987 (UniProt, ExPASy)
UniProt Secondary AC	E9PR17
Gene Symbol	CD59
GeneID	966
OMIM	107271
Buffer	0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on CD59 Glycoprotein (CD59)

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