HLA Class II Histocompatibility Antigen Gamma Chain (CD74) Antibody
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Catalogue No: abx004335
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US$217.50
(Size: 20 µl)
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Datasheet SDS
CD74 Antibody is a Rabbit Polyclonal antibody against CD74. The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Research Articles on HLA Class II Histocompatibility Antigen Gamma Chain (CD74)
| Target | HLA Class II Histocompatibility Antigen Gamma Chain (CD74) |
| Research Area | Cellular Differentiation and Adhesion, Immunology, Neuroscience, Developmental Science |
| Clonality | Polyclonal |
| Reactivity | Human, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 73-232 of human CD74. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P04233 (UniProt, ExPASy) |
| UniProt Entry Name | HG2A_HUMAN |
| Gene Symbol | CD74 |
| GeneID | 972 |
| NCBI Accession | NP_004346.1 |
| KEGG | hsa:972 |
| String | 9606.ENSP00000009530 |
| Molecular Weight | Calculated MW: 34 kDa Observed MW: 30-40 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |