CD86 Antibody is a Rabbit Polyclonal antibody against CD86. This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011].
| Target |
T-Lymphocyte Activation Antigen CD86 / B7-2 (CD86) |
| Clonality |
Polyclonal |
| Reactivity |
Human |
| Tested Applications |
WB, IF/ICC |
| Host |
Rabbit |
| Recommended dilutions |
WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation |
Unconjugated |
| Immunogen |
Recombinant protein of human CD86. |
| Isotype |
IgG |
| Form |
Liquid |
| Purification |
Affinity purified. |
| Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC |
P42081 (UniProt,
ExPASy)
|
| UniProt Entry Name |
CD86_HUMAN |
| Gene Symbol |
CD86 |
| GeneID |
942
|
| KEGG |
hsa:94
|
| String |
9606.ENSP00000332049
|
| Molecular Weight |
Calculated MW: 12 kDa, 24 kDa, 28 kDa, 31 kDa, 37 kDa
Observed MW: 80 kDa |
| Buffer |
PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| Concentration |
> 1 mg/ml |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
Research Articles on T-Lymphocyte Activation Antigen CD86 / B7-2 (CD86) Antibody
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