M-Phase Inducer Phosphatase 1 Phospho-Thr507 (CDC25A pT507) Antibody
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Catalogue No: abx031843
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US$326.25
(Size: 80 µl)
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Datasheet SDS
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.
Research Articles on M-Phase Inducer Phosphatase 1 Phospho-Thr507 (CDC25A pT507)
| Target | M-Phase Inducer Phosphatase 1 Phospho-Thr507 (CDC25A pT507) |
| Clonality | Polyclonal |
| Target Modification | Thr507 |
| Modification | Phosphorylation |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100, IF/ICC: 1/25. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T507 of human CDC25A. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by protein G affinity chromatography. Then, the antibody fraction was peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P30304 (UniProt, ExPASy) |
| UniProt Secondary AC | Q8IZH5, Q96IL3, Q9H2F2 |
| UniProt Entry Name | MPIP1_HUMAN |
| NCBI Accession | NP_001780.2 NP_963861.1 |
| KEGG | hsa:993 |
| String | 9606.ENSP00000303706 |
| Molecular Weight | Calculated MW: 59.1 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat and Cow CDC25A. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |