Cadherin-1 / E-Cadherin (CDH1) Antibody

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. This antibody is supplied as crude ascites.

Target	Cadherin-1 / E-Cadherin (CDH1)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Mouse
Recommended dilutions	WB: 1/5000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified His-tagged Human CDH1 protein
Isotype	IgG1
Form	Liquid
Purification	Unpurified crude ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P12830 (UniProt, ExPASy)
UniProt Secondary AC	A8K1U7, Q13799, Q14216, Q15855, Q16194, Q4PJ14, Q9UII8
UniProt Entry Name	CADH1_HUMAN
NCBI Accession	NP_004351.1
KEGG	hsa:999
String	9606.ENSP00000261769
Molecular Weight	Calculated MW: 97.5 kDa
Buffer	Ascites containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cadherin-1 / E-Cadherin (CDH1)

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