Cadherin-1 / E-Cadherin (CDH1) Antibody

CDH1 Antibody is a Rabbit Polyclonal antibody against CDH1. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008].

Target	Cadherin-1 / E-Cadherin (CDH1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 373-622 of human E-Cadherin.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P12830 (UniProt, ExPASy)
UniProt Secondary AC	A8K1U7, Q13799, Q14216, Q15855, Q16194, Q4PJ14, Q9UII8
UniProt Entry Name	CADH1_HUMAN
Gene Symbol	CDH1
GeneID	999
NCBI Accession	NP_004351.1
KEGG	hsa:999
String	9606.ENSP00000261769
Molecular Weight	Calculated MW: 97 kDa Observed MW: 125 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	0.53 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cadherin-1 / E-Cadherin (CDH1)

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