Cadherin 5 (CDH5) Antibody

CDH5 Antibody is a Rabbit Polyclonal antibody against CDH5. This gene is a classical cadherin from the cadherin superfamily and is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, the protein may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but its full length sequence has not been determined.

Target	Cadherin 5 (CDH5)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/100 - 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 259-358 of human VE Cadherin.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P33151 (UniProt, ExPASy)
UniProt Secondary AC	Q4VAI5, Q4VAI6
UniProt Entry Name	CADH5_HUMAN
Gene Symbol	CDH5
GeneID	1003
NCBI Accession	NP_001786.2
KEGG	hsa:1003
String	9606.ENSP00000344115
Molecular Weight	Calculated MW: 88 kDa Observed MW: 130 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cadherin 5 (CDH5)

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