Cyclin-Dependent Kinase 4 (CDK4) Antibody

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Catalogue No: abx000696
Price: US$203.00
(Size: 20 µl)

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Datasheet SDS
CDK4 Antibody is a Rabbit Polyclonal antibody against CDK4. The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

Target Cyclin-Dependent Kinase 4 (CDK4)
Clonality Polyclonal
Reactivity Human
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide corresponding to a sequence within amino acids 200-303 of human CDK4.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P11802 (UniProt, ExPASy)
UniProt Secondary AC B2R9A0, B4DNF9, O00576, Q6FG61
UniProt Entry Name CDK4_HUMAN
Gene Symbol CDK4
GeneID 1019
NCBI Accession NP_000066.1
KEGG hsa:1019
String 9606.ENSP00000257904
Molecular Weight Calculated MW: 34 kDa
Observed MW: 34 kDa
Buffer PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Cyclin-Dependent Kinase 4 (CDK4)


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