Cyclin Dependent Kinase 5 Activator 1 (CDK5R1) Antibody

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Catalogue No: abx033654
Price: US$326.25
(Size: 80 µl)

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Datasheet SDS
p35 is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5) ; the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

Target Cyclin Dependent Kinase 5 Activator 1 (CDK5R1)
Clonality Polyclonal
Reactivity Human
Tested Applications ELISA, WB, IHC
Host Rabbit
Recommended dilutions WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 272-301 amino acids from the C-terminal region of human CDK5R1 (p35).
Isotype IgG
Form Liquid
Purification Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q15078 (UniProt, ExPASy)
UniProt Secondary AC E1P664, Q5U0G3
UniProt Entry Name CD5R1_HUMAN
KEGG hsa:8851
String 9606.ENSP00000318486
Molecular Weight Calculated MW: 34.1 kDa
Buffer PBS containing 0.09% sodium azide.
Specificity Predicted to react with Mouse, Rat and Cow CDK5R1.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Cyclin Dependent Kinase 5 Activator 1 (CDK5R1)


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