Cyclin Dependent Kinase Inhibitor 1A (CDKN1A) Antibody

CDKN1A Antibody is a Rabbit Polyclonal antibody against CDKN1A. This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.

Target	Cyclin Dependent Kinase Inhibitor 1A (CDKN1A)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 1-164 of human CDKN1A/p21CIP1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P38936 (UniProt, ExPASy)
UniProt Secondary AC	Q14010, Q6FI05, Q9BUT4
UniProt Entry Name	CDN1A_HUMAN
Gene Symbol	CDKN1A
GeneID	1026
NCBI Accession	NP_000380.1
KEGG	hsa:1026
String	9606.ENSP00000384849
Molecular Weight	Calculated MW: 18 kDa Observed MW: 18 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cyclin Dependent Kinase Inhibitor 1A (CDKN1A)

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