Cyclin Dependent Kinase Inhibitor 1B (CDKN1B) Antibody

CDKN1B Antibody is a Rabbit Polyclonal antibody against CDKN1B. This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).

Target	Cyclin Dependent Kinase Inhibitor 1B (CDKN1B)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB, IF/ICC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IF/ICC: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human CDKN1B/p27KIP1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P46527 (UniProt, ExPASy)
UniProt Secondary AC	Q16307, Q5U0H2, Q9BUS6
UniProt Entry Name	CDN1B_HUMAN
Gene Symbol	CDKN1B
GeneID	1027
NCBI Accession	NP_004055.1
KEGG	hsa:1027
String	9606.ENSP00000228872
Molecular Weight	Calculated MW: 22 kDa Observed MW: 27 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cyclin Dependent Kinase Inhibitor 1B (CDKN1B)

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