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Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) Antibody

Catalogue No: abx000647
Price: £120.00
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Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) Antibody

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CDKN2A Antibody is a Rabbit Polyclonal antibody against CDKN2A. This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

Target CDKN2A
Clonality Polyclonal
Reactivity Human
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic peptide. C term –peptide of human CDKN2A.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P42771 (UniProt, ExPASy)
UniProt Entry Name CDN2A_HUMAN
Gene Symbol CDKN2A
GeneID 1029
KEGG hsa:102
String 9606.ENSP00000418915
Molecular Weight Calculated MW: 8 kDa, 11 kDa, 12 kDa, 13 kDa, 16 kDa, 17 kDa
Observed MW: 17 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Cyclin Dependent Kinase Inhibitor 2A (CDKN2A) Antibody

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