Centaurin-Gamma-1 (CENTG1) Antibody
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Catalogue No: abx026003
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US$326.25
(Size: 80 µl)
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GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1) dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
Research Articles on Centaurin-Gamma-1 (CENTG1)
| Target | Centaurin-Gamma-1 (CENTG1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 850-877 amino acids from the C-terminal region of human CENTG1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | Q99490 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K9F7, O00578, Q548E0, Q8IWU3 |
| UniProt Entry Name | AGAP2_HUMAN |
| Gene Symbol | AGAP2 |
| KEGG | hsa:116986 |
| String | 9606.ENSP00000449241 |
| Molecular Weight | Calculated MW: 125 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat AGAP2. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |