Centaurin-Gamma-1 (CENTG1) Antibody

GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1) dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.

Target	Centaurin-Gamma-1 (CENTG1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 850-877 amino acids from the C-terminal region of human CENTG1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q99490 (UniProt, ExPASy)
UniProt Secondary AC	A8K9F7, O00578, Q548E0, Q8IWU3
UniProt Entry Name	AGAP2_HUMAN
Gene Symbol	AGAP2
KEGG	hsa:116986
String	9606.ENSP00000449241
Molecular Weight	Calculated MW: 125 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat AGAP2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Centaurin-Gamma-1 (CENTG1)

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