CHEK1 (pS280) Antibody

CHEK1 (pS280) Antibody is a Rabbit Polyclonal antibody against CHEK1 (pS280). The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

Target	CHEK1 (pS280)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic phosphorylated peptide around S280 of human Chk1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O14757 (UniProt, ExPASy)
UniProt Secondary AC	A8K934, B4DDD0, B4DSK3, B5BTY6, F5H7S4, H2BI51
UniProt Entry Name	CHK1_HUMAN
Gene Symbol	CHEK1
GeneID	1111
NCBI Accession	NP_001265.2
KEGG	hsa:1111
String	9606.ENSP00000388648
Molecular Weight	Calculated MW: 54 kDa Observed MW: 54 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on CHEK1 (pS280)

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