CHEK1 (pS317) Antibody
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Catalogue No: abx000107
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US$232.00
(Size: 20 µl)
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Datasheet SDS
CHEK1 (pS317) Antibody is a Rabbit Polyclonal antibody against CHEK1 (pS317). The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.
Research Articles on CHEK1 (pS317)
| Target | CHEK1 (pS317) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic phosphorylated peptide around S317 of human Chk1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | O14757 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K934, B4DDD0, B4DSK3, B5BTY6, F5H7S4, H2BI51 |
| UniProt Entry Name | CHK1_HUMAN |
| Gene Symbol | CHEK1 |
| GeneID | 1111 |
| NCBI Accession | NP_001265.2 |
| KEGG | hsa:1111 |
| String | 9606.ENSP00000388648 |
| Molecular Weight | Calculated MW: 54 kDa Observed MW: 60 kDa |
| Buffer | PBS, pH 7.3, containing 0.09% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |