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CHEK1 (pS317) Antibody

Catalogue No: abx000107
Price: £120.00
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CHEK1 (pS317) Antibody CHEK1 (pS317) Antibody

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CHEK1 (pS317) Antibody is a Rabbit Polyclonal antibody against CHEK1 (pS317). The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

Target CHEK1 (pS317)
Clonality Polyclonal
Reactivity Human
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding S317 of human CHEK1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O14757 (UniProt, ExPASy)
UniProt Secondary AC A8K934, B4DDD0, B4DSK3, B5BTY6, F5H7S4, H2BI51
UniProt Entry Name CHK1_HUMAN
Gene Symbol CHEK1
GeneID 1111
KEGG hsa:111
String 9606.ENSP00000388648
Molecular Weight Calculated MW: 43 kDa, 50 kDa, 54 kDa
Observed MW: 60 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on CHEK1 (pS317) Antibody

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