Chemokine C-X-C-Motif Receptor 4 (CXCR4) Antibody
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Catalogue No: abx147379
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US$420.50
(Size: 100 µg)
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Datasheet SDS
Chemokine C-X-C-Motif Receptor 4 (CXCR4) Antibody is a Rabbit Polyclonal antibody for the detection of CXCR4. C-X-C chemokine receptor type 4 (CXCR4) is a widely expressed G protein-coupled seven-transmembrane receptor. CXCL12/SDF-1 is the biological ligand for CXCR4. The binding of CXCL12 to CXCR4 induces intracellular signaling through several divergent pathways initiating signals related to chemotaxis, cell survival and/or proliferation, increase in intracellular calcium, and gene transcription (PMID: 20484021). CXCR4 also functions as a coreceptor for HIV-1 entry (PMID: 9427609). CXCR4 has a calculated molecular weight of 40 kDa. In addition to the predicted species of 45-47 kDa for glycosylated CXCR4 monomers, due to ubiquitination, dimeration, and different degrees of glycosylation, additional species can also exist and have been reported in some researches, including 67 kDa (PMID: 23917520), 55, 67, 87 kDa (PMID: 20028517), 80 kDa (PMID: 10506573), 47, 50, 62, and 98 kDa (PMID: 16204649).
Research Articles on Chemokine C-X-C-Motif Receptor 4 (CXCR4)
| Target | Chemokine C-X-C-Motif Receptor 4 (CXCR4) |
| Research Area | Signal Transduction, Cellular Differentiation and Adhesion, Tumor Immunity, Infection Immunity, Cancer |
| Clonality | Polyclonal |
| Reactivity | Human, Rat |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | chemokine (C-X-C motif) receptor 4 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P61073 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R5N0, O60835, P30991, P56438, Q53S69, Q9BXA0, Q9UKN2 |
| UniProt Entry Name | CXCR4_HUMAN |
| Gene Symbol | CXCR4 |
| GeneID | 7852 |
| OMIM | 162643 |
| HGNC | 2561 |
| KEGG | hsa:7852 |
| Ensembl | ENSG00000121966 |
| String | 9606.ENSP00000386884 |
| Molecular Weight | Observed MW: 40 kDa, 55 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |