Serine/threonine-Protein Kinase Chk1 (CHK1) Antibody

HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. Amano T, et al. reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects. HRD1 contains one ring-type zinc finger.

Target	Serine/threonine-Protein Kinase Chk1 (CHK1)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 258-287 amino acids from human CHK1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	O14757 (UniProt, ExPASy)
UniProt Secondary AC	A8K934, B4DDD0, B4DSK3, B5BTY6, F5H7S4, H2BI51
UniProt Entry Name	CHK1_HUMAN
NCBI Accession	NP_001107593.1 NP_001107594.1 NP_001231775.1 NP_001265.2
KEGG	hsa:1111
String	9606.ENSP00000388648
Molecular Weight	Calculated MW: 54.4 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Serine/threonine-Protein Kinase Chk1 (CHK1)

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