Muscarinic Acetylcholine Receptor M2 (CHRM2) Antibody

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene.

Target	Muscarinic Acetylcholine Receptor M2 (CHRM2)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 336-364 amino acids from the Central region of human CHRM2.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P08172 (UniProt, ExPASy)
UniProt Secondary AC	Q4VBK6, Q9P1X9
UniProt Entry Name	ACM2_HUMAN
KEGG	hsa:1129
String	9606.ENSP00000399745
Molecular Weight	Calculated MW: 51.7 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat, Cow and Pig CHRM2.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Muscarinic Acetylcholine Receptor M2 (CHRM2)

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