Cholinergic Receptor, Nicotinic Alpha 10 (CHRNA10) Antibody

CHRNA10 is an ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.

Target	Cholinergic Receptor, Nicotinic Alpha 10 (CHRNA10)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 179-206 amino acids from the Central region of human CHRNA10.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9GZZ6 (UniProt, ExPASy)
UniProt Entry Name	ACH10_HUMAN
Gene Symbol	CHRNA10
String	9606.ENSP00000250699
Molecular Weight	Calculated MW: 49.7 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat CHRNA10.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cholinergic Receptor, Nicotinic Alpha 10 (CHRNA10)

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