Cold-Inducible RNA-Binding Protein (CIRBP) Antibody

CIRBP is cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. It acts as a translational activator and seems to play an essential role in cold-induced suppression of cell proliferation. It binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. This protein acts as a translational repressor (By similarity) and promotes assembly of stress granules (SGs), when overexpressed.

Target	Cold-Inducible RNA-Binding Protein (CIRBP)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 145-172 amino acids from the C-terminal region of human CIRBP.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q14011 (UniProt, ExPASy)
UniProt Secondary AC	B3KT17, B4E2X2
UniProt Entry Name	CIRBP_HUMAN
KEGG	hsa:1153
String	9606.ENSP00000466897
Molecular Weight	Calculated MW: 18.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat and Hamster CIRBP.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cold-Inducible RNA-Binding Protein (CIRBP)

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