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Circadian Locomoter Output Cycles Protein Kaput (CLOCK) Antibody
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Catalogue No: abx004307
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US$217.50
(Size: 20 µl)
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Datasheet SDS
CLOCK Antibody is a Rabbit Polyclonal antibody against CLOCK. The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants.
Research Articles on Circadian Locomoter Output Cycles Protein Kaput (CLOCK)
| Target | Circadian Locomoter Output Cycles Protein Kaput (CLOCK) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein corresponding to CLOCK. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | O15516 (UniProt, ExPASy) |
| UniProt Secondary AC | A0AV01, A2I2N9, O14516, Q9UIT8 |
| UniProt Entry Name | CLOCK_HUMAN |
| Gene Symbol | CLOCK |
| GeneID | 9575 |
| NCBI Accession | NP_004889.1 |
| KEGG | hsa:9575 |
| String | 9606.ENSP00000308741 |
| Molecular Weight | Calculated MW: 95 kDa Observed MW: 110 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |