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Creatine Kinase U-Type, Mitochondrial (CKMT1) Antibody
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Catalogue No: abx033156
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US$326.25
(Size: 80 µl)
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Datasheet SDS
Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase, this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase.
Research Articles on Creatine Kinase U-Type, Mitochondrial (CKMT1)
| Target | Creatine Kinase U-Type, Mitochondrial (CKMT1) |
| Research Area | Cardiovascular Biology |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 55-84 amino acids from the N-terminal region of human CKMT1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at 2-8°C for up to 2 weeks, or at -20°C for long term storage. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P12532 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DIT8, B7ZA09, Q0VAM3, Q32NF6, Q53FC4 |
| UniProt Entry Name | KCRU_HUMAN |
| Gene Symbol | CKMT1A |
| GeneID | 1159 548596 |
| OMIM | 123290 |
| HGNC | 31736 |
| KEGG | hsa:1159 hsa:548596 |
| Ensembl | ENSG00000237289 |
| String | 9606.ENSP00000406577 |
| Molecular Weight | Calculated MW: 47 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat, Cow and Pig CKMT1A. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |