Creatine Kinase U-Type, Mitochondrial (CKMT1) Antibody
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Catalogue No: abx004020
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US$217.50
(Size: 20 µl)
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Datasheet SDS
CKMT1 Antibody is a Rabbit Polyclonal antibody against CKMT1. Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.
Research Articles on Creatine Kinase U-Type, Mitochondrial (CKMT1)
| Target | Creatine Kinase U-Type, Mitochondrial (CKMT1) |
| Research Area | Cardiovascular Biology |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant protein corresponding to CKMT1. The exact sequence is proprietary. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P12532 (UniProt, ExPASy) |
| UniProt Secondary AC | B4DIT8, B7ZA09, Q0VAM3, Q32NF6, Q53FC4 |
| UniProt Entry Name | KCRU_HUMAN |
| Gene Symbol | CKMT1 |
| GeneID | 548596 |
| OMIM | 123290 |
| NCBI Accession | NP_001015001.1 |
| HGNC | 31736 |
| KEGG | hsa:548596 |
| Ensembl | ENSG00000237289 |
| String | 9606.ENSP00000406577 |
| Molecular Weight | Calculated MW: 47 kDa Observed MW: 47 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |