Creatine Kinase, Mitochondrial 1A (CKMT1A) Antibody

CKMT1A Antibody is a Rabbit Polyclonal antibody against CKMT1A. Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.

Target	Creatine Kinase, Mitochondrial 1A (CKMT1A)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 258-417 of human CKMT1A.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P12532 (UniProt, ExPASy)
UniProt Secondary AC	B4DIT8, B7ZA09, Q0VAM3, Q32NF6, Q53FC4
UniProt Entry Name	KCRU_HUMAN
Gene Symbol	CKMT1A
GeneID	548596
OMIM	123290
NCBI Accession	NP_001015001.1
HGNC	31736
KEGG	hsa:548596
Ensembl	ENSG00000237289
String	9606.ENSP00000406577
Molecular Weight	Calculated MW: 47 kDa Observed MW: 47 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Creatine Kinase, Mitochondrial 1A (CKMT1A)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue