Claudin 11 (CLDN11) Antibody

Catalogue No: abx002027
Price: £120.00
(Size: 20 µl)
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CLDN11 Antibody is a Rabbit Polyclonal antibody against CLDN11. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.

Target Claudin 11 (CLDN11)
Clonality Polyclonal
Reactivity Human
Tested Applications WB, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/20 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein of human CLDN11.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O75508 (UniProt, ExPASy)
UniProt Secondary AC B2R7C1, D3DNQ5, Q5U0P3
UniProt Entry Name CLD11_HUMAN
Gene Symbol CLDN11
GeneID 5010
KEGG hsa:5010
String 9606.ENSP00000064724
Molecular Weight Calculated MW: 21 kDa
Observed MW: 24 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Claudin 11 (CLDN11) Antibody

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