Calsyntenin 1 (CLSTN1) Antibody

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Catalogue No: abx030664
Price: US$290.00
(Size: 80 µl)

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Datasheet SDS
Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding. May modulate calcium-mediated postsynaptic signals (By similarity).

Target Calsyntenin 1 (CLSTN1)
Clonality Polyclonal
Reactivity Human
Tested Applications ELISA, WB
Host Rabbit
Recommended dilutions WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 15-42 amino acids from the N-terminal region of human CLSTN1.
Isotype IgG
Form Liquid
Purification Purified through a protein A column, followed by peptide affinity purification.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O94985 (UniProt, ExPASy)
UniProt Secondary AC A8K183, Q5SR52, Q5UE58, Q71MN0, Q8N4K9
UniProt Entry Name CSTN1_HUMAN
Gene Symbol CLSTN1
KEGG hsa:22883
String 9606.ENSP00000366513
Molecular Weight Calculated MW: 110 kDa
Buffer PBS containing 0.09% sodium azide.
Specificity Predicted to react with Mouse and Rat CLSTN1.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Calsyntenin 1 (CLSTN1)


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