Collagen Type XVIII Alpha 1 (COL18A1) Antibody

COL18A1 Antibody is a Rabbit Polyclonal antibody against COL18A1. This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].

Target	Collagen Type XVIII Alpha 1 (COL18A1)
Clonality	Polyclonal
Reactivity	Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 1050-1150 of human COL18A1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P39060 (UniProt, ExPASy)
UniProt Entry Name	COIA1_HUMAN
Gene Symbol	COL18A1
GeneID	80781
NCBI Accession	NP_085059.2
KEGG	hsa:80781
String	9606.ENSP00000347665
Molecular Weight	Calculated MW: 178 kDa Observed MW: 240 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Collagen Type XVIII Alpha 1 (COL18A1)

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