COP9 Signalosome Subunit 5 (COPS5) Antibody

COPS5 Antibody is a Rabbit Polyclonal antibody against COPS5. The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.

Target	COP9 Signalosome Subunit 5 (COPS5)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-334 of human JAB1/CSN5/JAB1/CSN5/COPS5.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q92905 (UniProt, ExPASy)
UniProt Secondary AC	O15386, Q6AW95, Q86WQ4, Q9BQ17
UniProt Entry Name	CSN5_HUMAN
Gene Symbol	COPS5
GeneID	10987
NCBI Accession	NP_006828.2
KEGG	hsa:10987
String	9606.ENSP00000350512
Molecular Weight	Calculated MW: 38 kDa Observed MW: 37 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	2.62 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on COP9 Signalosome Subunit 5 (COPS5)

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