Phospholipase A2, Cytosolic (cPLA2) Antibody

cPLA2 Antibody is a Rabbit Polyclonal antibody against cPLA2. This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.

Target	Phospholipase A2, Cytosolic (cPLA2)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 550-749 of human PLA2G4A.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P47712 (UniProt, ExPASy)
UniProt Secondary AC	B1AKG4, Q29R80
UniProt Entry Name	PA24A_HUMAN
Gene Symbol	PLA2G4A
GeneID	5321
NCBI Accession	NP_077734.1
KEGG	hsa:5321
String	9606.ENSP00000356436
Molecular Weight	Calculated MW: 85 kDa Observed MW: 115 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Phospholipase A2, Cytosolic (cPLA2)

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