Cytosolic Phospholipase A2 (PLA2G4A) Antibody
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Catalogue No: abx000706
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US$348.00
(Size: 60 µl)
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Datasheet SDS
PLA2G4A Antibody is a Rabbit Polyclonal antibody against PLA2G4A. This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
Research Articles on Cytosolic Phospholipase A2 (PLA2G4A)
| Target | Cytosolic Phospholipase A2 (PLA2G4A) |
| Research Area | Enzymes and Kinases, Metabolism, Cardiovascular Biology |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein corresponding to human PLA2G4A |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Shelf Life | 12 months. |
| UniProt Primary AC | P47712 (UniProt, ExPASy) |
| UniProt Secondary AC | B1AKG4, Q29R80 |
| UniProt Entry Name | PA24A_HUMAN |
| Gene Symbol | PLA2G4A |
| GeneID | 5321 |
| NCBI Accession | NP_077734.1 |
| KEGG | hsa:5321 |
| String | 9606.ENSP00000356436 |
| Molecular Weight | Calculated MW: 85 kDa Observed MW: 115 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Concentration | 1 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
