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CREB1 (pS133) Antibody

Catalogue No: abx000381
Price: £120.00
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CREB1 (pS133) Antibody is a Rabbit Polyclonal antibody against CREB1 (pS133). CREB1 is a transcription factor that is a member of the bZIP family of DNA binding proteins. It binds as a homodimer to the CRE (cAMP-Responsive Element), an octameric palindrome containing a conserved core sequence, 5-prime-TGACG-3-prime. It consists of two transcript variants encoding respective isoforms produced by alternate splicing. It is mapped to 2q32.3-q34. It is phosphorylated by several protein kinases and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. CREB1 is crucial for the consolidation of long-term conditioned fear memories, but not for encoding, storage, or retrieval of these memories. It is required for the stability of reactivated or retrieved conditioned fear memories.

Target CREB1 (pS133)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IHC
Host Rabbit
Recommended dilutions WB: 1/500 - 1/1000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Synthetic Peptide. A phospho specific peptide corresponding to residues surrounding S133 of human CREB1.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P16220 (UniProt, ExPASy)
UniProt Secondary AC P21934, Q6V963, Q9UMA7
UniProt Entry Name CREB1_HUMAN
Gene Symbol CREB1
GeneID 1385
String 9606.ENSP00000387699
Molecular Weight Calculated MW: 25 kDa, 35 kDa, 36 kDa
Observed MW: 43 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on CREB1 (pS133) Antibody

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