Adapter Molecule Crk (CRK) Antibody

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins.The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction.The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation.Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

Target	Adapter Molecule Crk (CRK)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IHC, IF/ICC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human CRK expressed in E. coli.
Isotype	IgG2b
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P46108 (UniProt, ExPASy)
UniProt Secondary AC	A8MWE8, B0LPE8, D3DTH6, Q96GA9, Q96HJ0
UniProt Entry Name	CRK_HUMAN
Gene Symbol	CRK
GeneID	1398
OMIM	164762
HGNC	2362
KEGG	hsa:1398
Ensembl	ENSG00000167193
String	9606.ENSP00000300574
Molecular Weight	42 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Adapter Molecule Crk (CRK)

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