CREB Regulated Transcription Coactivator 3 (CRTC3) Antibody

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites.Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation.Enhances the interaction of CREB1 with TAF4.Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR.Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells.Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).Tissue specificity: Predominantly expressed in B and T lymphocytes.Highest levels in lung.Also expressed in brain, colon, heart, kidney, ovary, and prostate.Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.

Target	CREB Regulated Transcription Coactivator 3 (CRTC3)
Clonality	Monoclonal
Reactivity	Human, Monkey
Tested Applications	ELISA, WB, IHC, IF/ICC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human CRTC3 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
GeneID	64784
Molecular Weight	68 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on CREB Regulated Transcription Coactivator 3 (CRTC3)

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