Gamma-Crystallin D (CRYGD) Antibody

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.

Target	Gamma-Crystallin D (CRYGD)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 73-101 amino acids from the Central region of human CRYGD.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P07320 (UniProt, ExPASy)
UniProt Secondary AC	Q17RF7, Q53R51, Q99681
UniProt Entry Name	CRGD_HUMAN
KEGG	hsa:1421
String	9606.ENSP00000264376
Molecular Weight	Calculated MW: 20.7 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat CRYGD.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Gamma-Crystallin D (CRYGD)

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