Tyrosine-Protein Kinase CSK (CSK) Antibody

Carboxy-terminal Src kinase (Csk) is a ubiquitously expressed nonreceptor tyrosine kinase that negatively regulates the Src family kinases (SFK) by phosphorylation of the SFK carboxy-terminal tyrosine.Phosphorylated carboxy-terminal tyrosine binds to the SH2 domain of SFK intramolecularly and leads to folding and inactivation of the SFK.This Csk-catalyzed SFK tyrosine phosphorylation is highly specific and exclusive.The SFK carboxy-terminal tyrosine is the only known physiological substrate of Csk.Tissue specificity: Expressed in lung and macrophages.

Target	Tyrosine-Protein Kinase CSK (CSK)
Clonality	Monoclonal
Reactivity	Human, Mouse, Monkey, Rat
Tested Applications	ELISA, WB, IF/ICC, FCM
Host	Mouse
Recommended dilutions	ELISA: 1/10000, WB: 1/500 - 1/2000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human CSK expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
GeneID	1445
Molecular Weight	50 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Tyrosine-Protein Kinase CSK (CSK)

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