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Transcriptional Repressor CTCF (CTCF) Antibody

Catalogue No: abx001047
Price: £120.00
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Transcriptional Repressor CTCF (CTCF) Antibody Transcriptional Repressor CTCF (CTCF) Antibody Transcriptional Repressor CTCF (CTCF) Antibody Transcriptional Repressor CTCF (CTCF) Antibody Transcriptional Repressor CTCF (CTCF) Antibody Transcriptional Repressor CTCF (CTCF) Antibody Transcriptional Repressor CTCF (CTCF) Antibody

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CTCF Antibody is a Rabbit Polyclonal antibody against CTCF. This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Target CTCF
Clonality Polyclonal
Reactivity Human, Mouse, Rat, Monkey
Tested Applications WB, IHC, IF/ICC, IP, ChIP
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IHC: 1/50 - 1/200, IF/ICC: 1/50 - 1/200, IP: 1/50 - 1/200, ChIP: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human CTCF (NP_006556.1).
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P49711 (UniProt, ExPASy)
UniProt Secondary AC B5MC38, Q53XI7, Q59EL8
UniProt Entry Name CTCF_HUMAN
Gene Symbol CTCF
GeneID 10664
String 9606.ENSP00000264010
Molecular Weight Calculated MW: 45 kDa, 82 kDa
Observed MW: 135 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Transcriptional Repressor CTCF (CTCF) Antibody

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