Troponin I, Cardiac Muscle (TNNI3) Antibody

Troponin I, Cardiac Muscle (TNNI3) has an apparent molecular weight of 22.5 kDa. cTnI is a candidate marker with acceptable sensitivity and specificity for AMI and other cardiac diseases. Troponin, a molecule that binds to the thin filament (actin) of striated muscle fibers, acts with intracellular calcium to control the interaction of the thin filament with the thick filament (myosin), thus regulating muscle contraction. Troponin I prevents muscle contraction in the absence of calcium, which has two skeletal muscle isoforms with considerable amino acid sequence homology. cTnI contains an additional N-terminal sequence and is highly specific for myocardium.

Target	Troponin I, Cardiac Muscle (TNNI3)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA, IHC
Host	Mouse
Recommended dilutions	ELISA: 1/10000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of cTnI expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Unpurified ascites.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P19429 (UniProt, ExPASy)
UniProt Entry Name	TNNI3_HUMAN
Gene Symbol	TNNI3
GeneID	7137
OMIM	115210
HGNC	11947
KEGG	hsa:7137
Ensembl	ENSG00000129991
String	9606.ENSP00000341838
Molecular Weight	18 kDa
Buffer	Ascitic fluid containing 0.03% sodium azide.
Concentration	Not determined.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Troponin I, Cardiac Muscle (TNNI3)

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