CTNNB1 (pY41 / S45) Antibody

CTNNB1 (pY41/S45) Antibody is a Rabbit Polyclonal antibody against CTNNB1 (pY41/S45). The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (pYR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.

Target	CTNNB1 (pY41/S45)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic phosphorylated peptide around T41 & S45 of human CTNNB1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P35222 (UniProt, ExPASy)
UniProt Secondary AC	A8K1L7, Q8NEW9, Q8NI94, Q9H391
Gene Symbol	CTNNB1
GeneID	1499
NCBI Accession	NP_001895.1
Molecular Weight	Calculated MW: 85 kDa Observed MW: 85 kDa
Buffer	PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on CTNNB1 (pY41/S45)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue