Cathepsin K (CTSK) Antibody

CTSK Antibody is a Rabbit Polyclonal antibody against CTSK. The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature.

Target	Cathepsin K (CTSK)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/100 - 1/500, IHC-P: 1/100 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 115-329 of human CTSK.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P43235 (UniProt, ExPASy)
UniProt Secondary AC	Q6FHS6
UniProt Entry Name	CATK_HUMAN
Gene Symbol	CTSK
GeneID	1513
NCBI Accession	NP_000387.1
KEGG	hsa:1513
String	9606.ENSP00000271651
Molecular Weight	Calculated MW: 37 kDa Observed MW: 39 kDa
Buffer	PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cathepsin K (CTSK)

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