Cullin 4A (CUL4A) Antibody

REQUEST MORE INFO
Catalogue No: abx002116
Price: US$203.00
(Size: 20 µl)

Click on the image to see the image legend

Available Options

* Size:




Add to Shopping Cart Buy It Now GET A QUOTE

Documents

Datasheet SDS
Cullin 4A Antibody is a Rabbit Polyclonal antibody against Cullin 4A. Cullin 4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins.Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC.

Target Cullin 4A (CUL4A)
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Tested Applications WB, IF/ICC, IP
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000, IF/ICC: 1/50 - 1/100, IP: 0.5-4 µg/200-400 µg whole cell extracts. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide corresponding to a sequence within amino acids 1-300 of human Cullin 4A.
Isotype IgG
Form Liquid
Purification Purified by affinity chromatography.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q13619 (UniProt, ExPASy)
UniProt Secondary AC A2A2W2, O75834, Q589T6, Q5TC62, Q6UP08, Q9UP17
UniProt Entry Name CUL4A_HUMAN
Gene Symbol CUL4A
GeneID 8451
NCBI Accession NP_001008895.1
KEGG hsa:8451
String 9606.ENSP00000364589
Molecular Weight Calculated MW: 88 kDa
Observed MW: 80 kDa
Buffer PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol.
Concentration > 0.2 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Cullin 4A (CUL4A)


Write a review