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Cullin 4A (CUL4A) Antibody

Catalogue No: abx002116
Price: £120.00
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Cullin 4A (CUL4A) Antibody

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Cullin 4A Antibody is a Rabbit Polyclonal antibody against Cullin 4A. Cullin 4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins.Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC.

Target Cullin 4A
Clonality Polyclonal
Reactivity Human, Mouse
Tested Applications WB
Host Rabbit
Recommended dilutions WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen A synthetic peptide of human CUL4A.
Isotype IgG
Form Liquid
Purification Affinity purified.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q13619 (UniProt, ExPASy)
UniProt Secondary AC A2A2W2, O75834, Q589T6, Q5TC62, Q6UP08, Q9UP17
UniProt Entry Name CUL4A_HUMAN
Gene Symbol CUL4A
GeneID 8451
KEGG hsa:8451
String 9606.ENSP00000364589
Molecular Weight Calculated MW: 76 kDa, 87 kDa
Observed MW: 95 kDa
Buffer PBS, pH 7.3, 0.02% sodium azide, 50% glycerol.
Concentration > 1 mg/ml
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on Cullin 4A (CUL4A) Antibody

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