Cullin 5 (CUL5) Antibody

Cullin 5 is a core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS (SOCS1) seems to direct ubiquitination of JAk2. It seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein and may form a cell surface vasopressin receptor.

Target	Cullin 5 (CUL5)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC, FCM
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 747-774 amino acids from the C-terminal region of human CUL5.
Isotype	IgG
Form	Liquid
Purification	Purified Rabbit Polyclonal Antibody.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q93034 (UniProt, ExPASy)
UniProt Secondary AC	A8K960, O14766, Q9BZC6
UniProt Entry Name	CUL5_HUMAN
KEGG	hsa:8065
String	9606.ENSP00000376808
Molecular Weight	Calculated MW: 91 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rabbit CUL5.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Cullin 5 (CUL5)

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